Xiaole Dun contains preservatives or affects corneal development
The same children's eye drops are sold in China with preservatives, but not in Japan. Recently, Mentholatum's brand Le Dun's eye drops have been exposed to double standards, causing widespread concern among consumers. Insiders pointed out that although Le Dun's eye drops contain preservative ingredients that meet domestic standards, Mentholatum's move is indeed a double standard. In this regard, Japan Le Dun Pharmaceutical Co., Ltd. and Mentholatum (China) Pharmaceutical Co., Ltd. jointly issued a statement acknowledging that Le Dun's eye drops sold in the Chinese market have added preservatives and are currently exploring the introduction of preservative-free eye drops in China. The feasibility of liquid products. ◇Exposure China Ledun Eye Drops have preservatives Nanfang Daily reporters log on to Mentholatum's official website to see that there are five main types of Le Dun's eye drops sold in the Chinese market: Xin Le Dun, Xiao Le Dun, Le Dun Qing, Le Dun Ying and Le Dun Kang, both of which are Mentholatum ( China National Pharmaceutical Co., Ltd. produces TCM external use drugs. When visiting several major pharmacies in Guangzhou, the reporter saw that the above five products were on sale, and the ingredients on their product packaging showed that all the preservatives were added. Among them, Xiaole Dun, Xinle Dun, and Le Dunkang are added benzalkonium chloride solution, and Le Dunying is added with concentrated chlorinated solution 50 (with benzalkonium chloride), which is added by Le Dunqing. Potassium sorbate. The data show that benzalkonium chloride, concentrated chlorinated solution 50, potassium sorbate are widely used in "preservation", and this ingredient is often contained in preservatives. Among the five products, the names of preservatives are all listed in the excipients, and those who lack chemical knowledge cannot identify them at all. According to industry insiders, the addition of preservatives in eye drops is a common phenomenon in the industry, and the reporter also found that the eye drops sold by many brands contain preservatives such as benzalkonium chloride. It is understood that according to China's "Administrative Measures for Pharmaceutical Excipients", preservatives can be used as an auxiliary for antibacterial in eye drops. In general, preservative-free drugs are more stringent and have a smaller capacity. It is understood that the preservative-free eye drops sold in China are mostly single-packages, each of which is used only within one day, and the price is generally expensive. Although domestic pharmacies can also buy anti-corrosive eye drops, sales will be affected by the difference in storage time and price. ◇ questioned Japanese eye drops without preservatives According to media reports, Le Dun's eye drops products are more abundant in China than in China, and most products also contain preservatives, which indicates that preservatives are also allowed to be added to eye drops in Japan. However, it is worth noting that Le Dun has clearly added no anti-corrosion on the boxes of children under the age of 15 (Kodomo soft, children's comfort) and teenagers (JR, juveniles). Agent. The same products sold in China contain preservatives. According to the Nanfang Daily reporter, the domestic production of LeDong eye drops is located in Zhongshan, Guangdong, and its affiliated company is Mentholatum (China). According to the official website, “Production equipment is imported from Mentholatum and Le Dun Pharmaceuticals in the United States†. Mentholatum (China) is a wholly-owned company of Mentholatum in China. Currently, Mentholatum has been acquired by Ledon Pharmaceuticals. Japan Le Dun Eye Liquid is produced by the Japanese Le Dun Pharmaceutical Factory. Since the company can produce preservative-free products, why are China and Japan still implementing double standards? In response to this question, on April 10, Japan’s Le Dun Pharmaceutical Co., Ltd. and Mentholatum (China) Pharmaceutical Co., Ltd. jointly issued a statement saying that the Xiaole Dun Eye Drops sold in the Japanese market is the second produced by Japan’s Leden Pharmaceuticals. New products, no preservatives. The Xiaole Dun eye drops in the Chinese market are the first generation products produced by Mentholatum (China), and the prescriptions used by Xiaole Dun Eye Drops in China and Japan are different. The statement also stated that the preservative used by Xiaole Dun meets the statutory standards and that the correct use of the product according to the instructions or the doctor's advice will not adversely affect consumers. The statement also stated that due to different pharmaceutical regulations in different countries, Mentholatum (China) Pharmaceutical Co., Ltd. is also exploring the feasibility of introducing preservative-free eye drops in China. ◇Hazardous preservatives or affecting corneal development in children Eye drops contain preservatives, how big is the hazard? In this regard, Tang Xilan, director of the Department of Pharmacy of Zhongshan Ophthalmic Center of Sun Yat-sen University, said that there are currently hundreds of eye drops on the market, of which more than 95% contain preservatives. At the same time, the state expressly stipulates that eye drops can be added with preservatives, and there are strict dose requirements, consumers do not need to panic. According to Tang Xilan, the presence of preservatives can effectively prevent microbial contamination from contact with air and humans after the eye drops are opened. Short-term and intermittent use of such eye drops will not cause adverse effects on consumers. However, Xie Like, director of the ophthalmology department of the Eye Hospital of China Academy of Chinese Medical Sciences, pointed out that the cornea is like a transparent protective wall, which protects the eyes, and is the first pass of external light into the eye, and the preservative will affect the growth and repair of corneal epithelial cells. "There are often patients in the department who have experienced tearing, foreign body sensation, dryness, redness, blurred vision. The cornea is carefully observed with a slit lamp microscope, and defects and irregularities are found. After the inquiry, it is known that the patient has long-term self-use eyes. The habit of potion." Xie Like reminded that for children, preservatives in eye drops have more hidden dangers. Some parents think that children use eye pressure and use them for long-term purchase of children's eye drops, which is actually harmful. He said that children are in the stage of growth and development, and the eyes are exposed to excessive preservatives in the eye drops. In addition to the above-mentioned phenomenon, the development of the cornea may also be affected. Experts pointed out that foreign countries have begun to use no preservatives in children's eye drops, and there is no set of targeted regulations for children's eye drops in China. At present, domestic eye drops face the same dilemma as other drugs. There is no distinction between adults and children in the regulations. Most doctors give drugs to patients in a short period of time. The main consideration of the therapeutic effect in the selection is that the preservatives are rarely considered. Experts call for multinational companies to implement the same highest standards globally. 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